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KMID : 0861020120270050009
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Korea Journal of Herbology
2012 Volume.27 No. 5 p.9 ~ p.14
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Protective effect of Poncirus trifoliata and Citrus aurantium extract on acute pancreatitis in mice model
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Park Kyoung-Chel
Bae Gi-Sang
Choi Sun-Bok
Jo Il-Joo
Gwak Tae-Sin
Lee Guem-San
Park Sung-Joo
Song Ho-Joon
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Abstract
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Objectives: We investigated the effect of Poncirus trifoliata and Citrus aurantium extract in mice with cerulein-induced acute pancreatitis (AP) model.
Methods: AP was induced via intraperitoneal injection of cerulein (50 ) given every hour for 6h. Poncirus trifoliata (PT: 200 or 400 mg/kg) and Citrus aurantium (CA: 200 or 400 mg/kg) extract were injected 1 h before in mice with cerulein-induced AP. Mice were sacrificed at 6 h after last injection of cerulein. Blood samples were taken to determine serum amylase and lipase levels. The pancreas and lungs were rapidly removed for morphological examination, myeloperoxidase assay.
Results: PT pre-treatment significantly protected the pancreas and lung damages and reduced the MPO activity and serum amylase in cerulein-induced AP. However, CA pre-treatment did not significantly protected the pancreas and lung inflammation in cerulein-induced AP. Conclusion : These results suggest that PT but not CA could protect the cerulein-induced AP.
Conclusions: These results suggest that PT but not CA could protect the cerulein-induced AP.
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KEYWORD
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Poncirus trifoliata (PT), Citrus aurantium (CA) Acute pancreatitis (AP), Amylase, Cerulein
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